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Inhibitors?ScreeningLibraries?Proteins

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Barasertib(Standard)

Cat.No.:HY-10127R

CASNo.:722543-31-9

Synonyms:AZD1152(Standard)

分?式:C??H??FN?O?P

分?量:587.54

作?靶点:AuroraKinase;Apoptosis

作?通路:CellCycle/DNADamage;Epigenetics;Apoptosis

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Barasertib(Standard)是Barasertib的分析标准品。本产品?于研究及分析应?。Barasertib(AZD1152)是

Barasertib-hQPA的前体化合物，是具有?度选择性的AuroraB抑制剂(IC50:0.37nM)。Barasertib可引起癌

细胞?长阻滞和凋亡(apoptosis)。

IC50TargetIC50:0.37nM(AuroraB)

REFERENCES

[1].YangJ,etal.AZD1152,anovelandselectiveauroraBkinaseinhibitor,inducesgrowtharrest,apoptosis,andsensitizationfortubulin

depolymerizingagentortopoisomeraseIIinhibitorinhumanacuteleukemiacellsinvitroandinvivo.Blood.2007Sep

[2].OkeA,etal.AZD1152rapidlyandnegativelyaffectsthegrowthandsurvivalofhumanacutemyeloidleukemiacellsinvitroandinvivo.

CancerRes.2009May15;69(10):4150-8.

[3].WilkinsonRW,etal.AZD1152,a