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Inhibitors?ScreeningLibraries?Proteins
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BACE1-IN-15
Cat.No.:HY-173226
分?式:C??H??F?N?O?S
分?量:335.33
作?靶点:Beta-secretase
作?通路:NeuronalSignaling
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性BACE1-IN-15(Compound72)是?种选择性的具有?服活性和?脑屏障穿透性的β-分泌酶1(BACE-1)抑制剂
，IC50值为121.65nM(对BACE-2的IC50值为480.92nM)。BACE1-IN-15可?于阿尔茨海默病领域的研究
[1]。
REFERENCES
[1].AfzalO,etal.Rationaldesign,docking,simulation,synthesis,andinvitrostudiesofsmallbenzothiazolemoleculesasselectiveBACE1
inhibitors.JBiomolStructDyn.2025Mar2:1-12.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE
1/1MasterofBioactiveMolecules—您?边的抑制剂?师