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文件名称：Decitabine-13C5-5-Aza-2-deoxycytidine-sup-13-sup-C-sub-5-sub-生命科学试剂-MCE.pdf
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更新时间：2025-05-22
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Decitabine-13C5

Cat.No.:HY-A0004S

Synonyms:5-Aza-2-deoxycytidine-13C;5-AZA-CdR-13C;NSC127716-13C

55

5

分?式:C???C?H??N?O?

分?量:231.15

作?靶点:Isotope-LabeledCompounds;DNAMethyltransferase;

NucleosideAntimetabolite/Analog;Apoptosis

作?通路:Others;Epigenetics;CellCycle/DNADamage;Apoptosis

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Decitabine-13C5(5-Aza-2-deoxycytidine-13C5)是13C标记的Decitabine.Decitabine(5-Aza-2-

deoxycytidine)是?种具有?服活性的脱氧胞苷类似物抗代谢物(deoxycytidineanalogueantimetabolite)和

DNA甲基转移酶(DNAmethyltransferase)抑制剂。Decitabine代替DNA掺?胞嘧啶可以将DNA甲基转移酶

共价捕获到DNA中，从?导致对该酶的不可逆抑制。Decitabine诱导细胞G2/M阻滞和细胞凋亡(

apoptosis)，并具有有效的抗癌活性。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs