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Cladribine-d4

Cat.No.:HY-13599S

Synonyms:2-Chloro-2′-deoxyadenosine-d;CldAdo-d;2CdA-d

444

分?式:C??H?D?ClN?O?

分?量:289.71

作?靶点:Isotope-LabeledCompounds

作?通路:Others

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Cladribine-d4(2-Chloro-2′-deoxyadenosine-d4)是氘代标记的Cladribine.Cladribine(2-Chloro-2′-

deoxyadenosine)是?种嘌呤核苷类似物，是具有?服活性的腺苷脱氨酶(adenosinedeaminase)抑制剂。

Cladribine能作为DNA合成(DNAsynthesis)的抑制剂，可阻断受损DNA的修复。Cladribine可以抑制DNA

甲基化。Cladribine具有抗淋巴瘤活性，可?于?些?液恶性肿瘤和多发性硬化的研究[1][2]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].Russak