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Inhibitors?ScreeningLibraries?Proteins

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4-Desmethyl-2-methylcelecoxib

Cat.No.:HY-Z7640

CASNo.:170569-99-0

分?式:C??H??F?N?O?S

分?量:381.37

作?靶点:COX

作?通路:Immunology/Inflammation

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性4-Desmethyl-2-methylcelecoxib(Compound1g)是?种具有?服活性和选择性的环氧化酶-2(COX-2)抑制剂

，IC50值为0.069μM。4-Desmethyl-2-methylcelecoxib具有抗炎、镇痛和解热活性。4-Desmethyl-2-

methylcelecoxib可以减少前列腺素的合成。4-Desmethyl-2-methylcelecoxib有望?于炎性疾病和疼痛相关

疾病的研究，如类风湿关节炎和?关节炎[1]。

IC50TargetCOX-2

0.069μM(IC50)

REFERENCES

[1].PenningTD,etal.Synthesisandbiologicalevaluationofthe1,5-diarylpyrazoleclassofcyclooxygenase-2inhibitors:identificationof4-

[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide(SC-58635,celecoxib).JMedChem.1997Apr25;40(9):1347-

65.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.