基本信息

---

下载

文档摘要

---

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

KMG-1068

Cat.No.:HY-172770

分?式:C??H??N?O?S

分?量:426.49

作?靶点:MolecularGlues

作?通路:PROTAC

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性KMG-1068(Compound4a)，?种分?胶(molecularglue)，是GSPT1/2降解剂。KMG-1068通过结合CRBN

上的IMiD结合位点，有效诱导CRBN依赖的GSPT1/2降解，促进与GSPT1/2形成三元配合物。KMG-1068有

望?于癌症的研究[1]。

REFERENCES

[1].ParkS,etal.DiscoveryofanovelmoleculargluedegradertargetingGSPT1/2withanon-IMiD-basedCRBNbinder.EurJMedChem.

2025Apr15;291:117642.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE

1/1MasterofBioactiveMolecules—您?边的抑制剂?师