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Inhibitors?ScreeningLibraries?Proteins
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Akt1-IN-8
Cat.No.:HY-173122
CASNo.:2247688-87-3
分?式:C??H??Br?N?O
分?量:551.28
作?靶点:Akt
作?通路:PI3K/Akt/mTOR
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Akt1-IN-8(CompoundJL18)是?种强效且?服?物可利?(41%)的AKT1激酶抑制剂，IC50值为8.8nM。
Akt1-IN-8对PC-3前列腺癌细胞表现出显著的抗增殖作?，IC50值为3.0μM。Akt1-IN-8可以降低磷酸化的
GSK3β?平。
IC50TargetAkt1
8.8nM(IC50)
REFERENCES
[1].SunJ,et,al.ThediscoveryofnovelN-heterocyclic-basedAKTinhibitorswithpotentialefficacyagainstprostatecancer.EurJMed
Chem.2025May5:289:117435.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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1/1MasterofBioactiveMolecules—您?边的抑制剂?师