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Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

HW161023

Cat.No.:HY-159931

CASNo.:2920698-73-1

分?式:C??H??F?N?O

分?量:374.43

作?靶点:AAK1

作?通路:NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性HW161023（compound）是?种?服有效的AP2相关蛋?激酶1(AAK1)抑制剂，其对AAK1和hERG的

IC50值分别为5.4nM和11.9μM。HW161023可抑制坐?神经慢性压迫损伤??模型的疼痛反应。

REFERENCES

[1].LiJ,etal.DiscoveryandevaluationofHW161023asapotentandorallyactiveAAK1inhibitor.BioorgMedChemLett.2024Dec

1;114:130012.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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1/1MasterofBioactiveMolecules—您?边的抑制剂?师