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Inhibitors?ScreeningLibraries?Proteins
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AX-53802
Cat.No.:HY-172761
CASNo.:1008482-71-0
分?式:C??H??FN?O?
分?量:408.42
作?靶点:GlutathionePeroxidase;Ferroptosis
作?通路:Apoptosis;MetabolicEnzyme/Protease
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性AX-53802是?种靶向GPX4的铁死亡(ferroptosis)诱导剂，IC50为0.34μM。AX-53802与GPX4形成共价键
，结合后直接启动膜转位。AX-53802和FAK/Src抑制剂联?可促进细胞死亡。AX-53802可?于癌症领域研究
[1]。
REFERENCES
[1].KunishigeR,etal.Proteincovariationnetworksforelucidatingferroptosisinducermechanismsandpotentialsynergisticdrugtargets.
CommunBiol.2025Mar31;8(1):480.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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1/1MasterofBioactiveMolecules—您?边的抑制剂?师