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Inhibitors?ScreeningLibraries?Proteins

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Vilanterol-d12

Cat.No.:HY-14300S2

Synonyms:GW642444-d12

分?式:C??H??D??Cl?NO?

分?量:498.5

作?靶点:Isotope-LabeledCompounds;AdrenergicReceptor

作?通路:Others;GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Vilanterol-d12(GW642444-d12)是氘代标记的Vilanterol.Vilanterol(GW642444)是?种长效的β2-AR激动

剂，效?持续24?时。对β2-AR，β1-AR和β3-AR的pEC50分别为10.37，6.98，7.36。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].SlackRJ,etal.Invitropharmacologicalcharacterizationofvilanterol,a