基本信息
文件名称：Danegaptide-d5-GAP-134-d-sub-5-sub-生命科学试剂-MCE.pdf
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更新时间：2025-05-22
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Danegaptide-d5

Cat.No.:HY-10913S

Synonyms:GAP-134-d;ZP1609-d

55

分?式:C??H??D?N?O?

分?量:296.33

作?靶点:Isotope-LabeledCompounds;GapJunctionProtein

作?通路:Others;Cytoskeleton

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Danegaptide-d5(GAP-134-d5)是氘代标记的Danegaptide.Danegaptide(GAP-134)是?种有效的，选择性

的，具有?服活性的gap-junction修饰剂，具有抗?律不齐的作?。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].JohnAButera,etal.Discoveryof(2S,4R)-1-(2-aminoacetyl)-4-be