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Zoniporidehydrochloridehydrate(Standard)

Cat.No.:HY-105064DR

CASNo.:863406-85-3

Synonyms:CP-597396hydrochloridehydrate(Standard)

分?式:C??H??ClN?O?

分?量:374.82

作?靶点:Na+/H+Exchanger(NHE)

作?通路:MembraneTransporter/IonChannel

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Zoniporide(hydrochloridehydrate)(Standard)是Zoniporide(hydrochloridehydrate)的分析标准品。本产

品?于研究及分析应?。Zoniporide(CP-597396)hydrochloridehydrate是1型钠氢交换剂(NHE-1)的有效

和选择性抑制剂。Zoniporidehydrochloridehydrate抑制?NHE-1(IC50=14nM)，与其他NHE亚型相?具

有?于150倍的选择性，并有效抑制离体NHE-1依赖性的???板溶胀(IC50=59nM)。

IC50TargetIC50:14nM(NHE-1)[1]

REFERENCES

[1].TraceyWR,etal.Zoniporide:apotentandselectiveinhibitorofthehumansodium-hydrogenexchangerisoform1(NHE-1).Cardiovasc

DrugRev.2003Spring;21(1):17-32.

[2].Guzman-PerezA,etal.Discoveryofzoniporide:apotentandselectivesodium-hydrogenexchangertype1(NHE-1)inhibitorwithhigh

aqueoussolubility.BioorgMedChe