Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Saracatinib(Standard)

Cat.No.:HY-10234R

CASNo.:379231-04-6

Synonyms:AZD0530(Standard)

分?式:C??H??ClN?O?

分?量:542.03

作?靶点:Src;Autophagy

作?通路:ProteinTyrosineKinase/RTK;Autophagy

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Saracatinib(Standard)是Saracatinib的分析标准品。本产品?于研究及分析应?。Saracatinib(AZD0530)是

?种有效的Src抑制剂，抑制c-Src，Lck，c-YES，Lyn，Fyn，Fgr和Blk的IC50值为2.7-11nM，对其他酪氨

酸激酶具有选择性。

IC50TargetIC50:2.7nM(Src),30nM(v-Abl),66nM(EGFR),200nM(c-Kit)[1]

REFERENCES

[1].GreenTP,etal.Preclinicalanticanceractivityofthepotent,oralSrcinhibitorAZD0530.MolOncol,2009,3(3),248-261.

[2].FuseMA,etal.CombinationTherapyWithc-MetandSrcInhibitorsInducesCaspase-DependentApoptosisofMerlin-DeficientSchwann

CellsandSuppressesGrowthofSchwannomaCells.MolCancerTher.MolCancerTher.2017Nov;16(11):2387-2398.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.