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文件名称：Rabeprazole-13C-d3-sodium-LY307640-sup-13-sup-C-d-sub-3-sub-sodium-生命科学试剂-MCE.pdf
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更新时间：2025-05-23
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Rabeprazole-13C,d3sodium

Cat.No.:HY-B0656AS3

Synonyms:LY307640-13C,dsodium

3

分?式:C????CH??D?N?NaO?S

分?量:385.44

作?靶点:Isotope-LabeledCompounds;Apoptosis;Bacterial;Proton

Pump

作?通路:Others;Apoptosis;Anti-infection;MembraneTransporter/Ion

Channel

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Rabeprazole-13C,d3(sodium)(LY307640-13C,d3(sodium))是13C标记的Rabeprazole(sodium).

Rabeprazolesodium(LY307640sodium)是?种?代质?泵抑制剂(pumpinhibitor,PPI)，不可逆地抑制胃

H+/K+-ATPase。Rabeprazolesodium诱导细胞凋亡(apoptosis)。Rabeprazolesodium也抑制尿苷核苷核糖

?解酶(UNH)，IC50为0.3μM[1]。Rabeprazolesodium可?于胃溃疡和胃?管反流的研究[1][2][3]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationh