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Inhibitors?ScreeningLibraries?Proteins

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PD146176(Standard)

Cat.No.:HY-103157R

CASNo.:4079-26-9

Synonyms:NSC168807(Standard)

分?式:C??H??NS

分?量:237.32

作?靶点:Autophagy;Ferroptosis

作?通路:Autophagy;Apoptosis

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性PD146176(Standard)是PD146176的分析标准品。本产品?于研究及分析应?。PD146176(NSC168807)是

?种15-脂氧合酶(15-LO)抑制剂，对兔?织红细胞15-LO有抑制作?(Ki=197nM,IC50=0.54μM)。

PD146176通过刺激?年三重转基因??的?噬作?逆转认知障碍、脑淀粉样变性和tau病理学。

IC50TargetKi:197nM(Rabbitreticulocyte15-LO)[1]

IC50:0.54μM[2]

REFERENCES

[1].SendobrySM,etal.Attenuationofdiet-inducedatherosclerosisinrabbitswithahighlyselective15-lipoxygenaseinhibitorlacking

significantantioxidantproperties.BrJPharmacol.1997;120(7):1199-1206.

[2].BocanTM,etal.Aspecific15-lipoxygenaseinhibitorlimitstheprogressionandmonocyte-macrophageenrichmentof

hypercholesterolemia-inducedatherosclerosisintherabbit[publishedcorrectionappearsinAtheroscl