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Inhibitors?ScreeningLibraries?Proteins

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Pamapimod(Standard)

Cat.No.:HY-10405R

CASNo.:449811-01-2

Synonyms:Ro4402257(Standard);R1503(Standard)

分?式:C??H??F?N?O?

分?量:406.38

作?靶点:p38MAPK;Autophagy

作?通路:MAPK/ERKPathway;Autophagy

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Pamapimod(Standard)是Pamapimod的分析标准品。本产品?于研究及分析应?。Pamapimod

(Ro4402257)是?种有效的，选择性和?服活性的p38MAPK抑制剂，对于p38α和p38β的IC50分别为14

nM和480nM，Ki分别为1.3nM和120nM。Pamapimod对p38δ或p38γ亚型没有活性。Pamapimod

可?于类风湿关节炎和其他??免疫性疾病的研究。

REFERENCES

[1].Hill,R.J.etal.Pamapimod,anovelp38mitogen-activatedproteinkinaseinhibitor:preclinicalanalysisofefficacyandselectivity.The

Journalofpharmacologyandexperimentaltherapeutics327,610-619,doi:10.1124/jpet.108.139006(2008).

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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