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Granisetron-d6Hydrochloride

Cat.No.:HY-B0071AS

Synonyms:BRL43694A-d6

分?式:C??H??D?ClN?O

分?量:354.91

作?靶点:Isotope-LabeledCompounds;5-HTReceptor

作?通路:Others;GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Granisetron-d6(Hydrochloride)(BRL43694A-d6)是氘代标记的Granisetron(Hydrochloride).

Granisetron(BRL43694A)盐酸盐是5-HT3受体拮抗剂，可作为化疗后?吐剂。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].SangerGJ,NelsonDR.Selectiveandfunctional5-hydroxytryptamine3receptorantagonismbyBRL43694(gran