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Fenofibricacid-d4

Cat.No.:HY-B0760S2

Synonyms:FNFacid-d4

分?式:C??H??D?ClO?

分?量:322.78

作?靶点:Isotope-LabeledCompounds

作?通路:Others

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Fenofibricacid-d4(FNFacid-d4)是氘代标记的Fenofibricacid.Fenofibricacid是fenofibrate的活性代谢物

，为PPAR激动剂，对PPARα，PPARγ和PPARδ的EC50值分别为22.4μM，1.47μM和1.06μ

M；Fenofibricacid同时可抑制COX-2的活性，IC50值为48nM。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

McePdfHeight

Caution:Producthasnotbeenfullyvalidated