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Inhibitors?ScreeningLibraries?Proteins
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Cambinol(Standard)
Cat.No.:HY-100732R
CASNo.:14513-15-6
分?式:C??H??N?O?S
分?量:360.43
作?靶点:Sirtuin;Apoptosis;Phospholipase
作?通路:CellCycle/DNADamage;Epigenetics;Apoptosis;Metabolic
Enzyme/Protease
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Cambinol(Standard)是Cambinol的分析标准品。本产品?于研究及分析应?。Cambinol是?种SIRT1和
SIRT2的抑制剂，IC50值分别为56μM和59μM。Cambinol是中性鞘磷脂酶(N-SMase)的抑制剂(外泌体抑
制剂)。
IC50TargetIC50:56μM(SIRT1),59μM(SIRT2)[1]
REFERENCES
[1].HeltwegB,etal.Antitumoractivityofasmall-moleculeinhibitorofhumansilentinformationregulator2enzymes.CancerRes.2006Apr
15;66(8):4368-77.
[2].HuaruiZhang,etal.Advancesinthediscoveryofexosomeinhibitorsincancer.JEnzymeInhibMedChem.2020Dec;35(1):1322-1330.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.