Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
4F-Docetaxel
Cat.No.:HY-173387
CASNo.:912272-09-4
Synonyms:4FDT
分?式:C??H??F?NO??
分?量:879.84
作?靶点:Others
作?通路:Others
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性4F-Docetaxel(4FDT)是?种氟化多西他赛类似物。4F-Docetaxel具有抗肝癌活性，可?于肝细胞癌(HCC)的
研究[1]。
体外研究4F-Docetaxelshowscytotoxicactivityagainstseveraltumorcelllines,withIC50sof0.049μM(95-D),0.070μ
M(SKOV3),0.958μM(HCT-116),0.021μM(HepG2),0.022μM(Bel-7402),0.014μM(SMMC-7721),0.011
μM(SGC-7901),0.043μM(MDA-MB-231),0.017μM(A2780),0.012μM(KB),0.006μM(HL-60),6.6μM
(U2OS),respectively[1].
REFERENCES
[1].HaoYP,etal.Novelfluorinateddocetaxelanalogforanti-hepatoma:Moleculardockingandbiologicalevaluation.EurJPharmSci.2016
Jun10;88:274-81.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.