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Xanomelinetartrate(Standard)

Cat.No.:HY-105182AR

CASNo.:152854-19-8

Synonyms:LY246708tartrate(Standard)

分?式:C??H??N?O?S

分?量:431.5

作?靶点:mAChR

作?通路:GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Xanomeline(tartrate)(Standard)是Xanomeline(tartrate)的分析标准品。本产品?于研究及分析应?。

Xanomeline(LY246708)是具有抗精神病样活性的毒蕈碱M1/M4受体的有效激动剂。Xanomeline(LY

246708)增加神经元兴奋性。Xanomeline(LY246708)可?于研究精神分裂症[1][2][3]。

IC50TargetM1/M4[1]

REFERENCES

[1].KreirM,etal.RoleofKv7.2/Kv7.3andM1muscarinicreceptorsintheregulationofneuronalexcitabilityinhiPSC-derivedneurons.EurJ

Pharmacol.2019;858:172474.

[2].ShekharA,etal.Selectivemuscarinicreceptoragonistxanomelineasanoveltreatmentapproachforschizophrenia.AmJPsychiatry.

2008;165(8):1033-1039.

[3].AndersenMB,etal.ThemuscarinicM1/M4receptoragonistxanomelineexhibitsantipsychotic-likeactivityinCebusapellamonkeys.

Neuropsych