Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
WAY-100635(Standard)
Cat.No.:HY-10349R
CASNo.:162760-96-5
分?式:C??H??N?O?
分?量:422.56
作?靶点:5-HTReceptor;DopamineReceptor
作?通路:GPCR/GProtein;NeuronalSignaling
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性WAY-100635(Standard)是WAY-100635的分析标准品。本产品?于研究及分析应?。WAY-100635是?种
有效且具有选择性的5-hydroxytryptamine1A(5-HT1A)受体拮抗剂，其IC50值为0.91nM，Ki值为0.39
nM。WAY-100635对于5-HT1A和α1-肾上腺素的pIC50值分别为8.9和6.6。WAY-100635也是?种有效的
多巴胺D4受体激动剂。
IC50TargetpIC50Value:8.87(5-HT1AReceptor)[1].
REFERENCES
[1].ChemelBR,etal.WAY-100635isapotentdopamineD4receptoragonist.Psychopharmacology(Berl).2006Oct;188(2):244-51.
[2].MannucciC,etal.SerotonininvolvementinRhodiolaroseaattenuationofnicotinewithdrawalsignsinrats.Phytomedicine.2012Sep
15;19(12):1117-24.
[3].AlHussainyR,etal.Design,synthesis,radiolabeling,andinvitroandinvivoevaluationofbridgeheadiodinatedanaloguesofN-{2-[4-(2-
methoxyphenyl)piperazin-