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Inhibitors?ScreeningLibraries?Proteins

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Verapamil-d6

Cat.No.:HY-14275S2

Synonyms:(±)-Verapamil-d;CP-16533-1-d

66

分?式:C??H??D?N?O?

分?量:460.64

作?靶点:Isotope-LabeledCompounds

作?通路:Others

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Verapamil-d6((±)-Verapamil-d6)是氘代标记的Verapamil.Verapamil((±)-Verapamil)是?种钙通道(

calciumchannel)阻滞剂，是?种有效的?服活性的第?代P糖蛋?(P-gp)抑制剂。Verapamil能也抑制

CYP3A4，并可?于??压，?律不齐和?绞痛的研究。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

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