Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
TGX-221(Standard)
Cat.No.:HY-10114R
CASNo.:663619-89-4
分?式:C??H??N?O?
分?量:364.44
作?靶点:PI3K
作?通路:PI3K/Akt/mTOR
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性TGX-221(Standard)是TGX-221的分析标准品。本产品?于研究及分析应?。TGX-221是?种?效的、选择性
的、细胞膜渗透的PI3Kp110β抑制剂，常?于癌症研究。
IC50TargetIC50:8.5nM(p110β),211nM(p110δ)[5]
REFERENCES
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[2].GeQ,etal.Thephosphoinositide3-kinasep110δmodulatescontractileproteinproductionandIL-6releaseinhumanairwaysmooth
muscle.JCellPhysiol.2012Aug;227(8):3044-52.
[3].MüllerKM,etal.RoleofproteinkinaseCandepidermalgrowthfactorreceptorsignallingingrowthstimulationbyneurotensinincolon
carcinomacells.BMCCancer.2011Oct2;11:421.
[4].SturgeonSA,etal.Advantagesofaselectivebeta-isoformphosphoinositide3-kinaseantagonist,ananti-thromboticagentdevoidof
othercardiov