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文件名称：Tariquidar-methanesulfonate-hydrate-Standard-XR9576-methanesulfonate-hydrate-Standard-生命科学试剂-MCE.pdf
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更新时间：2025-05-23
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Tariquidarmethanesulfonate,hydrate(Standard)

Cat.No.:HY-10550AR

CASNo.:625375-83-9

Synonyms:XR9576methanesulfonate,hydrate(Standard)

分?式:C??H??N?O??S?

分?量:892.99

作?靶点:P-glycoprotein

作?通路:MembraneTransporter/IonChannel

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Tariquidar(methanesulfonate,hydrate)(Standard)是Tariquidar(methanesulfonate,hydrate)的分析标准品

。本产品?于研究及分析应?。Tariquidarmethanesulfonate,hydrate(XR9576methanesulfonate,hydrate)

是有效和特异性的P-glycoprotein(P-gp)抑制剂，Kd值为5.1nM。

IC50TargetKd:5.1nM(P-gp)[1]

REFERENCES

[1].MartinC,etal.ThemolecularinteractionofthehighaffinityreversalagentXR9576withP-glycoprotein.BrJPharmacol,1999,128(2),

403-411.

[2].MistryP,etal.InvitroandinvivoreversalofP-glycoprotein-mediatedmultidrugresistancebyanovelpotentmodulator,XR9576.

CancerRes,2001,61(2),749-758.

[3].VrakaC,etal.AnewmethodmeasuringtheinteractionofradiotracerswiththehumanP-glyco