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Inhibitors?ScreeningLibraries?Proteins

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Talazoparib-d4

Cat.No.:HY-16106S1

Synonyms:BMN-673-d;LT-673-d

44

分?式:C??H??D?F?N?O

分?量:384.38

作?靶点:Isotope-LabeledCompounds;PARP

作?通路:Others;CellCycle/DNADamage;Epigenetics

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Talazoparib-d4(BMN-673-d4)是氘代标记的Talazoparib.Talazoparib(BMN-673)是?种?效的，具有?服活

性的PARP1/2抑制剂。Talazoparib抑制PARP1和PARP2酶活性的Ki值分别为1.2nM和0.87nM。

Talazoparib具有抗肿瘤活性[1]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;