基本信息
文件名称：S-Lisinopril-d5-sodium-MK-521-d-sub-5-sub-sodium-生命科学试剂-MCE.pdf
文件大小：466.39 KB
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更新时间：2025-05-23
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

(S)-Lisinopril-d5sodium

Cat.No.:HY-18206S1

CASNo.:1356847-28-3

Synonyms:MK-521-dsodium

5

分?式:C??H??D?N?NaO?

分?量:432.5

作?靶点:Isotope-LabeledCompounds;Angiotensin-convertingEnzyme

(ACE)

作?通路:Others;MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性(S)-Lisinopril-d5(sodium)(MK-521-d5(sodium))是氘代标记的Lisinopril.Lisinopril(MK-521)是?管紧张素

转化酶抑制剂，可作?于??压，充?性??衰竭和?脏病等。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):2