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SKP-451
Cat.No.:HY-171469
CASNo.:181137-41-7
分?式:C??H??N?O?
分?量:346.33
作?靶点:PotassiumChannel
作?通路:MembraneTransporter/IonChannel
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性SKP-451是?种ATP敏感的钾(K+)通道激动剂。SKP-451激活ATP敏感的K+通道，促进K+的外排，引起膜
超极化，抑制Ca2+的内流，从?使?管平滑肌松弛。SKP-451放松?冠状动脉、兔基底动脉和椎动脉。SKP-
451还能降低有意识?发性??压??(SHR)的平均动脉?压。SKP-451有望?于??管疾病的研究[1]。
REFERENCES
[1].HongKW,etal.PharmacologicalprofilesofSKP-450anditsfamily,aK+channelopener,incomparisonwithlevcromakalim.Pharmacol
Res.1998Sep;38(3):191-7.
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