Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

RS-102221hydrochloride(Standard)

Cat.No.:HY-101365AR

CASNo.:187397-18-8

分?式:C??H??ClF?N?O?S

分?量:649.08

作?靶点:5-HTReceptor

作?通路:GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性RS-102221(hydrochloride)(Standard)是RS-102221(hydrochloride)的分析标准品。本产品?于研究及分析

应?。RS-102221hydrochloride是?种选择性5-HT2C受体拮抗剂(Ki=10nM)。RS-102221hydrochloride

对5-HT2C受体的选择性是5-HT2A和5-HT2B受体的近100倍。RS-102221hydrochloride能够促进新?神经

细胞分化。RS-102221hydrochloride增加了??的?物摄?量和体重增加。

REFERENCES

[1].BortolottoV,etal.ProneurogenicEffectsofTrazodoneinMurineandHumanNeuralProgenitorCells.ACSChemNeurosci.2017Sep

20;8(9):2027-2038.

[2].BonhausDW,etal.RS-102221:anovelhighaffinityandselective,5-HT2Creceptorantagonist.Neuropharmacology.1997Apr-

May;36(4-5):621-9.

[3].SalzerI,etal.Controlofsensoryneuronexcitabilitybyserotonininvolves5HT2CreceptorsandCa(2+)-activatedchloridechannels.

Neuropharmacolog