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Piromelatine(Standard)

Cat.No.:HY-105285R

CASNo.:946846-83-9

Synonyms:Neu-P11(Standard)

分?式:C??H??N?O?

分?量:312.32

作?靶点:MelatoninReceptor;5-HTReceptor;P2XReceptor;TRP

Channel;SodiumChannel

作?通路:GPCR/GProtein;NeuronalSignaling;Membrane

Transporter/IonChannel

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Piromelatine(Standard)是Piromelatine的分析标准品。本产品?于研究及分析应?。Piromelatine(Neu-

P11)是褪?素受体MT1/MT2的激动剂，是5-HT1A和5-HT1D的激动剂，也是5-HT2B的拮抗剂。

Piromelatine(Neu-P11)有?于促进睡眠、缓解疼痛、抗神经退?性和抗抑郁等研究的潜能。Piromelatine

(Neu-P11)还具有抑制疼痛相关靶点P2X3、TRPV1和Nav1.7通道的活性。

REFERENCES

[1].MeihuaShe,etal.Piromelatine,aNovelMelatoninReceptorAgonist,StabilizesMetabolicProfilesandAmelioratesInsulinResistancein

ChronicSleepRestrictedRats.EurJPharmacol.2014Mar15;727:60-5.

[2].LHuang,etal.BloodPressureReducingEffectsofPiromelatineandMelatonininSpontaneouslyHy