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Nicotinamide-d3

Cat.No.:HY-B0150S3

CASNo.:2162970-00-3

Synonyms:Niacinamide-d;Nicotinicacidamide-d

33

分?式:C?H?D?N?O

分?量:125.14

作?靶点:Isotope-LabeledCompounds;EndogenousMetabolite;

Organoid;Sirtuin;HBV

作?通路:Others;MetabolicEnzyme/Protease;StemCell/Wnt;Cell

Cycle/DNADamage;Epigenetics;Anti-infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Nicotinamide-d3(Niacinamide-d3)是氘代标记的Nicotinamide.Nicotinamide是维?素B3或烟酸的?种形

式。Nicotinamide可抑制SIRT2的活性，其IC50值为2μM。Nicotinamide也抑制SIRT1。Nicotinamide增

加细胞内NAD+、ATP、ROS?平。Nicotinamide抑制肿瘤?长并提??存率。NicotinamideHydrochloride

还具有抗-HBV活性。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSub