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Inhibitors?ScreeningLibraries?Proteins

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Lexibulin(Standard)

Cat.No.:HY-10498R

CASNo.:917111-44-5

Synonyms:CYT-997(Standard)

分?式:C??H??N?O?

分?量:434.53

作?靶点:Microtubule/Tubulin;ReactiveOxygenSpecies;Apoptosis

作?通路:CellCycle/DNADamage;Cytoskeleton;

Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κ

B;Apoptosis

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Lexibulin(Standard)是Lexibulin的分析标准品。本产品?于研究及分析应?。Lexibulin(CYT-997)是微管蛋

?聚集强效抑制剂，对多种癌细胞的IC50值为10-100nM，体外体内具有?效的细胞毒性和?管增?阻断作

?。Lexibulin可诱导细胞凋亡(apoptosis)，并诱导GC细胞中的线粒体ROS?成。

IC50TargetIC50value:10-100nM(cellassay)[1]

REFERENCES

[1].BurnsCJ,etal.CYT997:anovelorallyactivetubulinpolymerizationinhibitorwithpotentcytotoxicandvasculardisruptingactivityinvitro

andinvivo.MolCancerTher.2009Nov;8(11):3036-45.

[2].MonaghanK,etal.CYT997causesapoptosisinhumanmultiplemyeloma.InvestNewDrugs.2011Apr;29(2):232-8.