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Laduviglusibmonohydrochloride(Standard)

Cat.No.:HY-10182AR

CASNo.:1797989-42-4

Synonyms:CHIR-99021monohydrochloride(Standard);CT99021

monohydrochloride(Standard)

分?式:C??H??Cl?N?

分?量:501.8

作?靶点:Organoid;GSK-3;Wnt;β-catenin;Autophagy

作?通路:StemCell/Wnt;PI3K/Akt/mTOR;Autophagy

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Laduviglusib(monohydrochloride)(Standard)是Laduviglusib(monohydrochloride)的分析标准品。本产品

?于研究及分析应?。Laduviglusib(CHIR-99021)monohydrochloride是?种有效的选择性GSK-3α/β抑制

剂，IC50为10nM和6.7nM。Laduviglusibmonohydrochloride对GSK-3的选择性?CDC2，ERK2和其他

蛋?激酶?500倍以上。Laduviglusibmonohydrochloride还是?种有效的Wnt/β-catenin信号通路激活剂

。Laduviglusibmonohydrochloride可增强??和?类胚胎?细胞的?我更新。Laduviglusib

monohydrochloride能诱导细胞?噬(autophagy)。

IC50TargetIC50:10nM/6.7nM(GSK-3α/β)[1]

REFERENCES

[1].RingDB,etal.Selectiveglycogensynthasekinas