基本信息
文件名称：Indinavir-13C4-15N-MK-639-free-base-sup-13-sup-C-sub-4-sub-sup-15-sup-N-生命科学试剂-MCE.pdf
文件大小：659.99 KB
总页数：2 页
更新时间：2025-05-23
总字数：约3.88千字
文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Indinavir-13C4,15N

Cat.No.:HY-B0689S1

Synonyms:MK-639freebase-13C,15N;L-735524freebase-13C,15N

44

分?式:C????C?H??N???NO?

分?量:618.75

作?靶点:Isotope-LabeledCompounds;Apoptosis;MMP;HIV;SARS-

CoV;HIVProtease

作?通路:Others;Apoptosis;MetabolicEnzyme/Protease;Anti-infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Indinavir-13C4,15N(MK-639(freebase)-13C4,15N)是13C和15N标记的Indinavir.Indinavir(MK-639free

base)是?种?服有效并且具有选择性的HIV-1蛋?酶抑制剂，其对PR的Ki值为0.54nM。Indinavir可通过

抑制基质?属蛋?酶-2?解的激活，抗?管?成以及促癌细胞凋亡来发挥抗癌活性。Indinavir也是?种SARS-

CoV3CLpro抑制剂。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention