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Inhibitors?ScreeningLibraries?Proteins

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Imeglimin-d3

Cat.No.:HY-14771S

Synonyms:EMD387008-d3

分?式:C?H??D?N?

分?量:157.23

作?靶点:Isotope-LabeledCompounds;MitochondrialMetabolism;

ReactiveOxygenSpecies

作?通路:Others;MetabolicEnzyme/Protease;

Immunology/Inflammation;NF-κB

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Imeglimin-d3(EMD387008-d3)是氘代标记的Imeglimin.Imeglimin(EMD387008)是?种?服降糖剂。

Imeglimin可改善胰岛素敏感性。Imeglimin还减少活性氧(ROS)的产?，增加了线粒体DNA，并改善线粒体

功能[1]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmaco