Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Difelikefalin-d5

Cat.No.:HY-17609S

Synonyms:CR-845-d;FE-202845-d

55

分?式:C??H??D?N?O?

分?量:684.88

作?靶点:Isotope-LabeledCompounds;OpioidReceptor

作?通路:Others;GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Difelikefalin-d5(CR-845-d5)是氘代标记的Difelikefalin.Difelikefalin(CR-845;FE-202845)是选择性的κ阿

?受体(KOR)激动剂。Difelikefalin具有抗炎作?，并在慢性肾脏病等疾病中具有调节瘙痒的潜?。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].Steven