Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Ciprofloxacin-d4

Cat.No.:HY-B0356S2

Synonyms:Bay-09867-d4

分?式:C??H??D?FN?O?

分?量:335.37

作?靶点:Isotope-LabeledCompounds;MitochondrialMetabolism;

ReactiveOxygenSpecies;Topoisomerase;Apoptosis;

Bacterial;Antibiotic

作?通路:Others;MetabolicEnzyme/Protease;

Immunology/Inflammation;NF-κB;CellCycle/DNADamage;

Apoptosis;Anti-infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Ciprofloxacin-d4(Bay-09867-d4)是氘代标记的Ciprofloxacin.Ciprofloxacin(Bay-09867)是?种?服有效的

拓扑异构酶IV抑制剂。Ciprofloxacin诱导线粒体DNA和核DNA损伤并导致线粒体功能障碍和活性氧产?。

Ciprofloxacin具有抗增殖活性并诱导细胞凋亡(apoptosis)。Ciprofloxacin是?种氟喹诺酮类抗?素，具有强

?的抗菌活性。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPhar