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Inhibitors?ScreeningLibraries?Proteins

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Cetrorelix-d10

Cat.No.:HY-P0009S1

Synonyms:SB-75-d10

分?式:C??H??D??ClN??O??

分?量:1441.1

作?靶点:Isotope-LabeledCompounds;GnRHReceptor

作?通路:Others;GPCR/GProtein

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Cetrorelix-d10(SB-75-d10)是氘代标记的Cetrorelix.Cetrorelix是?种有效的促性腺激素释放激素(GnRH)拮

抗剂。Cetrorelix抑制卵巢刺激过程中的内源性促黄体激素激增。Cetrorelix可减少环磷酰胺诱导的??卵巢滤

泡破坏[1][2]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].DiedrichK,etal.Suppressionoftheendogenousluteinizinghormonesurgebythegonadotr