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文件名称：Canertinib-dihydrochloride-Standard-CI-1033-dihydrochloride-Standard-生命科学试剂-MCE.pdf
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Canertinibdihydrochloride(Standard)

Cat.No.:HY-10367AR

CASNo.:289499-45-2

Synonyms:CI-1033dihydrochloride(Standard);PD-183805

dihydrochloride(Standard)

分?式:C??H??Cl?FN?O?

分?量:558.86

作?靶点:EGFR;Orthopoxvirus

作?通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK;Anti-

infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Canertinib(dihydrochloride)(Standard)是Canertinib(dihydrochloride)的分析标准品。本产品?于研究及分

析应?。Canertinibdihydrochloride(CI-1033;PD-183805)是有效地，不可逆的EGFR抑制剂；抑制细胞

EGFR和ErbB2??磷酸化的IC50值分别为7.4和9nM。Canertinibdihydrochloride可以?于研究??的?

痘病毒呼吸道感染。

IC50TargetIC50:7.4nM(EGFR),9nM(ErbB2)[1]

REFERENCES

[1].SmaillJB,etal.Tyrosinekinaseinhibitors.17.Irreversibleinhibitorsoftheepidermalgrowthfactorreceptor:4-

(phenylamino)quinazoline-and4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamidesbearingadditionalsolubilizingfunctio