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Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Brigatinib-d11

Cat.No.:HY-12857S2

CASNo.:2055306-76-6

Synonyms:AP-26113-d11

分?式:C??H??D??ClN?O?P

分?量:595.16

作?靶点:Isotope-LabeledCompounds;Anaplasticlymphomakinase

(ALK)

作?通路:Others;ProteinTyrosineKinase/RTK

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Brigatinib-d11(AP-26113-d11)是氘代标记的Brigatinib.Brigatinib(AP-26113)是?种有效，选择性的，具有

?服活性的ALK抑制剂，IC50值为0.6nM。Brigatinib可?于??细胞肺癌(NSCLC)的研究[1]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.