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Inhibitors?ScreeningLibraries?Proteins
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Autotaxin-IN-7
Cat.No.:HY-170227
分?式:C??H??N?O?
分?量:484.51
作?靶点:Phosphodiesterase(PDE);TGF-βReceptor
作?通路:MetabolicEnzyme/Protease;TGF-beta/Smad
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Autotaxin-IN-7(45)是?种吡啶-2-羧酸衍?物，表现出亚纳摩尔级别的ATX抑制作?(IC50=0.086nM)，具
有?脏安全性良好的特点(hERG30μM)，且对纤维母细胞的毒性最?。Autotaxin-IN-7(45)抑制TGF-β/
Smad信号通路，下调α-平滑肌肌动蛋?(α-SMA)和细胞外基质成分(ECM)。Autotaxin-IN-7(45)可?于研
究肺纤维化。
REFERENCES
[1].DeyiMa,etal.DevelopmentofTricyclic4,5-Dihydro-3H-pyrrolo[2,3-c]quinolin-4-onesasPotentAutotaxinInhibitorsforPulmonary
FibrosisTreatmentInVivo.JMedChem.2025Apr10;68(7):7476-7498.
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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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