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Inhibitors?ScreeningLibraries?Proteins
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AKTligand-2
Cat.No.:HY-48682
CASNo.:2376139-61-4
分?式:C??H??ClN?O?
分?量:597.15
作?靶点:LigandsforTargetProteinforPROTAC
作?通路:PROTAC
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性AKTligand-2(compound5)是?种AKT配体。AKTligand-2可以通过连接?与VHL配体(S,R,S)-AHPC(HY-
125845)结合，合成PROTACMS21(HY-141807)[1]。
REFERENCES
[1].XuJ,etal.AKTDegradationSelectivelyInhibitstheGrowthofPI3K/PTENPathway-MutantCancerswithWild-TypeKRASandBRAF
byDestabilizingAuroraKinaseB.CancerDiscov.2021Dec
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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