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Xanomeline(Standard)

Cat.No.:HY-105182R

CASNo.:131986-45-3

Synonyms:LY-246708(Standard)

分?式:C??H??N?OS

分?量:281.42

作?靶点:mAChR

作?通路:GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Xanomeline(Standard)是Xanomeline的分析标准品。本产品?于研究及分析应?。Xanomeline作为?种有

效的选择性毒蕈碱1型和4型(M1/M4)受体激动剂可增加神经元兴奋性。Xanomeline可?于精神分裂症等神

经障碍的研究[1][2]。

IC50TargetM1/M4[1][2]

REFERENCES

[1].KreirM,etal.RoleofKv7.2/Kv7.3andM1muscarinicreceptorsintheregulationofneuronalexcitabilityinhiPSC-derivedneurons.EurJ

Pharmacol.2019;858:172474

[2].ShekharA,etal.Selectivemuscarinicreceptoragonistxanomelineasanoveltreatmentapproachforschizophrenia.AmJPsychiatry.

2008;165(8):1033-1039.

[3].AndersenMB,etal.ThemuscarinicM1/M4receptoragonistxanomelineexhibitsantipsychotic-likeactivityinCebusapellamonkeys.

Neuropsychopharmacology.2003;28(6):1168-1175.

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