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Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
SCH442416(Standard)
Cat.No.:HY-103169R
CASNo.:316173-57-6
分?式:C??H??N?O?
分?量:389.41
作?靶点:AdenosineReceptor
作?通路:GPCR/GProtein
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性SCH442416(Standard)是SCH442416的分析标准品。本产品?于研究及分析应?。SCH442416是?种有效
，选择性和可透过?脑屏障的腺苷A2A受体(A2AR)拮抗剂，对?和??A2AR的Ki值分别为0.048和0.5
nM。SCH442416在A1R，A2BR和A3R(Ki=1111，10000，10000nM)上显?出超过23000倍的选择性。
SCH442416可?于在??和灵长类动物?脑中对腺苷A2A受体成像。
IC50TargetIC50:0.048nM(hA2AR),0.5nM(rA2AR)[1]
REFERENCES
[1].ToddeS,et,al.Design,radiosynthesis,andbiodistributionofanewpotentandselectiveligandforinvivoimagingoftheadenosine
A(2A)receptorsystemusingpositronemissiontomography.JMedChem.2000Nov16;43(23):4359-62.
[2].MorescoRM,et,al.InvivoimagingofadenosineA2Areceptorsinratandprimatebrainusing[11C]SCH442416.EurJNuclMedMol
Imaging.2005Apr;32(4):405-13.
[3].ZhengJ,et,al.Protectiverolesofadenos