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文件名称：Raltegravir-d4-potassium-MK-0518-d-sub-4-sub-potassium-生命科学试剂-MCE.pdf
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Raltegravir-d4potassium

Cat.No.:HY-10353AS2

Synonyms:MK0518-dpotassium

4

分?式:C??H??D?FKN?O?

分?量:486.53

作?靶点:Isotope-LabeledCompounds;HIV;HIVIntegrase

作?通路:Others;Anti-infection;MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Raltegravir-d4(potassium)(MK0518-d4(potassium))是氘代标记的Raltegravir(potassium).Raltegravir

(MK0518)potassium是?种有效的integrase抑制剂，?于研究HIV感染。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

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