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Inhibitors?ScreeningLibraries?Proteins

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Bexarotene-13C6

Cat.No.:HY-14171S2

Synonyms:LGD1069-13C6

分?式:C????C?H??O?

分?量:350.4

作?靶点:Isotope-LabeledCompounds;RAR/RXR;Autophagy

作?通路:Others;MetabolicEnzyme/Protease;VitaminD

Related/NuclearReceptor;Autophagy

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Bexarotene-13C6(LGD1069-13C6)是13C标记的Bexarotene.Bexarotene(LGD1069)是?种?亲和?的选择

性类视黄醇X受体(RXR)激动剂，对RXRα、RXRβ和RXRγ的EC50分别为33、24、25nM。Bexarotene

对RAR受体的亲和?有限(EC5010000nM)[1][2][3]。Bexarotene可?于?肤T细胞淋巴瘤的研究。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticso