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Inhibitors?ScreeningLibraries?Proteins

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THIP(Standard)

Cat.No.:HY-10232R

CASNo.:64603-91-4

Synonyms:Gaboxadol(Standard)

分?式:C?H?N?O?

分?量:140.14

作?靶点:GABAReceptor

作?通路:MembraneTransporter/IonChannel;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性THIP(Standard)是THIP的分析标准品。本产品?于研究及分析应?。THIP(Gaboxadol)是?种选择性的突触

外GABAA受体(eGABARs)激动剂(可透过?脑屏障)，对δ-GABAAR的EC50值为13μM。THIP在第2/3层

神经元中诱导强烈的紧张性GABAA介导的电流，但不影响微型IPSCs。THIP可?于睡眠障碍的研究。

REFERENCES

[1].DrasbekKR,etal.THIP,ahypnoticandantinociceptivedrug,enhancesanextrasynapticGABAAreceptor-mediatedconductancein

mouseneocortex.CerebCortex.2006Aug;16(8):1134-41.

[2].LarsenM,etal.5-Hydroxy-L-tryptophanaltersgaboxadolpharmacokineticsinrats:involvementofPAT1andrOat1ingaboxadol

absorptionandelimination.EurJPharmSci.2010Jan31;39(1-3):68-75.

[3].Hoestgaard-JensenK,etal.Probingα4βδGABAAreceptorheterogeneity:differentialregionaleffectsofafunctionallyselective

α4β1δ/α4