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Inhibitors?ScreeningLibraries?Proteins

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Splitomicin(Standard)

Cat.No.:HY-100585R

CASNo.:5690-03-9

Synonyms:Splitomycin(Standard)

分?式:C??H??O?

分?量:198.22

作?靶点:HDAC

作?通路:CellCycle/DNADamage;Epigenetics

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Splitomicin(Standard)是Splitomicin的分析标准品。本产品?于研究及分析应?。Splitomicin(Splitomycin)

是?种选择性的Sir2p抑制剂。Splitomicin抑制Sir2蛋?的NAD+依赖性HDAC活性。Splitomicin抑制酵母

提取物中HDAC，IC50为60μM[1]。

REFERENCES

[1].BedalovA,etal.IdentificationofasmallmoleculeinhibitorofSir2p.ProcNatlAcadSciUSA.2001Dec18;98(26):15113-8.

[2].BreitensteinA,etal.Sirt1inhibitionpromotesinvivoarterialthrombosisandtissuefactorexpressioninstimulatedcells.CardiovascRes.

2011Feb1;89(2):464-72.

[3].OtaH,etal.Sirt1inhibitor,Sirtinol,inducessenescence-likegrowtharrestwithattenuatedRas-MAPKsignalinginhumancancercells.

Oncogene.2006Jan12;25(2):176-85.

McePdfHeight

Caution:Producthasnotbeenfullyvalidated