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Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

YM-58483(Standard)

Cat.No.:HY-100831R

CASNo.:223499-30-7

Synonyms:BTP2(Standard)

分?式:C??H?F?N?OS

分?量:421.32

作?靶点:CRACChannel

作?通路:MembraneTransporter/IonChannel

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性YM-58483(Standard)是YM-58483的分析标准品。本产品?于研究及分析应?。YM-58483(BTP2)是?种有

效的CRACchannels抑制剂，能够抑制Ca2+信号。YM-58483阻断钙池操纵的阳离?内流(SOCE)[1][2]。

REFERENCES

[1].QiZ,etal.TheCentralAnalgesicMechanismofYM-58483inAttenuatingNeuropathicPaininRats.CellMolNeurobiol.2016

Oct;36(7):1035-43

[2].OhgaK,etal.CharacterizationofYM-58483/BTP2,anovelstore-operatedCa2+entryblocker,onTcell-mediatedimmuneresponsesin

vivo.IntImmunopharmacol.2008Dec20;8(13-14):1787-9

[3].OhgaK,etal.ThesuppressiveeffectsofYM-58483/BTP-2,astore-operatedCa2+entryblocker,oninflammatorymediatorreleasein

vitroandairwayresponsesinvivo.PulmPharmacolTher.2008;21(2):360-9

[4].YoshinoT,etal.YM-58483,aselectiveCRACchannelinhibitor,