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HydroxyItraconazole-d6

Cat.No.:HY-12772S3

Synonyms:R-63373-d6

分?式:C??H??D?Cl?N?O?

分?量:727.67

作?靶点:Isotope-LabeledCompounds;Fungal

作?通路:Others;Anti-infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性HydroxyItraconazole-d6(R-63373-d6)是氘代标记的HydroxyItraconazole.HydroxyItraconazole

(ItraconazolemetaboliteHydroxyItraconazole;R-63373)是Itraconazole(ITZ)的活性代谢物，Itraconazole

是?种三唑类抗真菌剂。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].MinoY,etal.Hydroxy-itraconazolepharmacokineticsissi